- Open Access
Evaluation of the effectiveness of comprehensive drug price reform: a case study from Shihezi city in Western China
International Journal for Equity in Health volume 19, Article number: 133 (2020)
China carried out a comprehensive drug price reform (CDPR) in 2017 to control the growing expense of drug effectively and reduce the financial burden of inpatients. However, early studies in pilot regions found the heterogeneity in the effectiveness of CDPR from different regions and other negative effects. This study aimed to evaluate the effects of the reform on medical expenses, medical service utilisation and government financial reimbursement for inpatients in economically weaker regions.
Shihezi was selected as the sample city, and 238,620 inpatients, who were covered by basic medical insurance (BMI) and had complete information from September 2016 to August 2018 in public hospitals, were extracted by cluster sampling. An interrupted series design was used to compare the changing trends in medical expenses, medical service utilisation and reimbursement of BMI for inpatients before and after the reform.
Compared with the baseline trends before the CDPR, those after the CDPR were observed with decreased per capita hospitalisation expenses (HE) by ¥301.9 per month (p < 0.001), decreased drug expense (DE) ratio at a rate of 0.32% per month (p < 0.05) and increased ratio of diagnosis and treatment expenses (DTE) at a rate of 0.25% per month (p < 0.01). The number of inpatients in secondary and tertiary hospitals declined by 458 (p < 0.001) and 257 (p < 0.05) per month, respectively. The BMI reimbursement in tertiary hospitals decreased by ¥254.7 per month (p < 0.001).
The CDPR controlled the increase in medical expenses effectively and adjusted its structure reasonably. However, it also reduced the medical service utilisation of inpatients in secondary and tertiary hospitals and financial reimbursement for inpatients in tertiary hospitals.
The rapid increase in drug price puts considerable strain on the affordability and sustainability of healthcare spending [1, 2]. According to a report on global drug use survey, global drug expenditures that reached $1.2 trillion in 2018 will exceed $1.5 trillion by 2023, and the average annual growth rate will be 3 to 6%. Meanwhile, most (73%) of the global drug expenditure is in US, EU5 (i.e. Germany, France, Italy, U.K. and Spain), Japan and China . In the past decades, many countries have explored the implementation paths of drug price reforms, such as drug–price regulation, payment reform of medical insurance, combination of drug–price regulation and drug–use reduction, to curb the rising drug expenditures [2, 4,5,6,7,8]. These reforms have reduced drug prices in the short-term but are unsustainable and have even produced unexpected results, such as a rebound in drug costs [4, 7,8,9].
In China, the long-term surge of drug expense (DE) is because medical service prices are lower than the labour costs of medical staff . However, public hospitals can make a 15% profit in prescribing drugs to make up for the deficit in the low prices of medical services . The relationship between hospital medical revenue and DE has led to an artificial rise in drug prices and a surge in hospitalisation expenses (HE) [12, 13]. Another reason for the increase in DE is associated with the basic medical insurance (BMI) payment regime. In China, the BMI fund compensates inpatients for medical expenses more than outpatients . Moreover, the compensations for medical expenses amongst inpatients vary by hospitals. That is, the higher the hospital tier, the lower the compensations of medical expenses. The purpose is to reduce the financial burden of inpatients and guide the patients to rationally choose a hospital according to their health status . However, it has not limited the patients’ behaviour for seeking healthcare service , so a large number of patients seeking high-quality medical service bypass primary hospitals to visit secondary and tertiary hospitals, thereby increasing unnecessary medical expenses . According to statistics, the DE in public hospitals exceeded 30% of the per capita HE between the years 2007 and 2017, up to even 40% (Additional file 1 Fig. S1), far higher than 17% in the member countries of the Organization for Economic Co-operation and Development . In the face of this situation, the Chinese government promulgated three guiding opinions on the pilot of the comprehensive reform of urban public hospitals, the reform of medical service price and the reform of BMI payment methods from 2015 to 2017 [15, 18, 19]. The comprehensive drug price reform (CDPR) has begun to take shape.
Shihezi, a city of Xinjiang Production and Construction Corps (XPCC), is located in western China where the economic development lags behind the eastern and central regions . Meanwhile, it is one of the core region of China’s “silk road economic belt” and the maintenance of national stability. At present, the city’s population accounts for 21% of the XPCC’s total population, and its health expenditure exceeds 3% of the national average health expenditure [21, 22]. According to statistics, the population aged 65 years and older in Shihezi accounts for 17% of the total population in 2015, exceeding the national average of 5.5%, and the prevalence of chronic diseases has reached 599.3‰ [23, 24]. These findings can further aggravate the utilisation rate of hospitalisation services and stimulate the growth of health expenses . In 2017, all public hospitals in China have implemented the CDPR officially . In September 2017, Shihezi launched the CDPR, which involves three aspects, namely, eliminating the 15% drug profit, increasing the medical service price to make up the loss of drug price and scientifically adjusting BMI payment standards to ensure that the first two reforms do not increase the financial burden of patients.
Literature review revealed that DE shows a downward trend in regions where the above reforms have started early. By the end of 2016, more than 90% of public hospitals from 200 pilot cities nationwide have cancelled drug markup, and the proportion of DE in HE have shown a negative growth (from 36.8% in 2015 to 34.6% in 2016) for the first time . However, the accumulated evidences in the literature showed that HE paid by the BMI funds also has a downward trend [28,29,30]. A study found that the drug price level in western low-income regions such as Gansu and Yunnan was higher than that in eastern high-income regions such as Beijing and Jiangsu, suggesting that the CDPR may ignore the imbalance of economic development in various regions . A study from economically developed region found that some public hospitals made more profits by over-delivery of medical services and over-admission of patients . Above evidences indicated differences in the actual implementation of reform policy by local governments at the local level, the lack of effective linkage between the policies of adjusting medical service price and adjusting BMI payment, and the excessive utilisation of medical services. So far, except for a study on a single-institution , no large population size has been used to study the effectiveness of the CDPR in the XPCC. Based on the above situation, it is urgent to clarify the effects of the CDPR in this city, which will have an important impact on the population health and economic development of XPCC in the future.
In view of the positive and negative effects of early drug price reforms in the pilot regions and the heterogeneity in the effects of CDPR from different regions, the objective of the current study is to evaluate the effectiveness of CDPR through the changing trends in medical expenses, medical service utilisation and government financial reimbursement for inpatients before and after the CDPR in Shihezi. These findings will provide the basis for promoting the health equity of the residents in regions with weak economic development and provide a reference for countries and regions with similar of economical development and health expenditure to formulate and improve drug reform policies.
Materials and methods
Data were obtained from the database of the Social Insurance Administration Bureau in Shihezi City. Cluster sampling was used to extract the data of 245,730 inpatients covered by BMI in public hospitals between September 2016 and August 2018 from the database. The collected data were processed anonymously, and each patient was identified by a unique identification code. Excluding 7110 inpatients with incomplete data information, 238,620 inpatients from 30 public hospitals were retained.
The data included baseline characteristics and medical expenses for inpatients. The baseline characteristics included age (< 65 and ≥ 65), sex (male and female), medical institution (primary, secondary and tertiary hospitals) and BMI [urban employee medical insurance (UEMI) and urban and rural resident medical insurance (URRMI)]. The medical expenses for inpatients included HE, DE, diagnosis and treatment expense (DTE) and BMI reimbursement.
An interrupted time series design was used to compare the per capita medical expenses of inpatients before and after the CDPR that came into effect on September 1, 2017 . The interrupted time series analysis (ITSA) is the strongest quasi experimental study that can effectively evaluate the change in the outcome rate in the time periods before and after implementation of a policy, especially in the absence of a control group . In the present study, the effect of policy changes was measured using the following equation:
In the equation, Yt is the independent outcome variable of medical expenses at time t (i.e. time unit is the number of months). Time is a continuous variable representing the months since the start of the study, policy is a dummy (indicator) variable representing the pre-CDPR (September 2016 to August 2017 and coded 0) and the post-CDPR (September 2017 to August 2018 and coded 1) periods and time after policy is a continuous variable representing the number of months since September 2017 and is coded as zero before September 2017. β0 represents the baseline level of the outcome variable, β1 represents the slope of the outcome variable before the reform, β2 represents the change in the outcome level occurring in the period immediately following the implementation of the reform and β3 represents the difference between pre- and post-reform slopes of the outcome .
Eight outcome variables, namely, number of inpatients, per capita HE, per capita DE and DE ratio, per capita DTE and DTE ratio, per capita BMI reimbursement and reimbursement ratio, were analysed (Table 1). The number of inpatients was measured as an indicator of medical service utilisation in inpatients. The per capita HE and DE and DTE ratios were measured as indicators to evaluate the effects of the control and structural adjustment for medical expenses. The BMI reimbursement and the reimbursement ratio were measured as indicators to reflect government financial reimbursement for inpatients.
Data analysis consisted of three stages. Firstly, the baseline characteristics between the pre- and the post-CDPR periods were analysed as frequencies and percentages for categorical variables. Secondly, the outcome variables were calculated monthly between September 2016 and August 2018. Finally, ITSA was used to analyse the effects of implementing the CDPR. The Newey–West method was used to handle heteroscedasticity and autocorrelation. The Actest was used to test autocorrelation and determine the number of time-series lags to ensure that the model conforms to the correct autocorrelation structure . The STATA statistical software version 14 was used for this analysis.
Inpatient characteristics and medical expenses
The final sample included 238,620 inpatients. A total of 123,980 and 114,640 were included in the pre- and post-CDPR periods, respectively. The age, sex and medical insurance distributions of inpatients were similar between the two CDPR periods (Table 2). The median age was 61 years (interquartile range = 49 years to 74 years), 43.8% of total inpatients were 65 years and older, 54.5% were female, and 77.9% were UEMI. The distribution of inpatients admitted to primary hospitals increased from 43.0 to 50.9%, and the distributions of inpatients in secondary and tertiary hospitals decreased by 4.5 and 3.3%, respectively (Table 2).
ITSA results of medical expenses and its compositions
In the pre-CDPR period, evident growth trends were observed in per capita HE (¥124.2 per month; 95% CI = 52.8 to 195.6, p < 0.01), and the DE and DTE ratios remained unchanged. However, the introduction of the CDPR was followed by sudden reductions in per capita HE (¥ − 1112.4; 95% CI = − 1610.5 to − 614.3, p < 0.001) and DE ratio (− 2.08% per month; 95% CI = − 3.52 to − 0.64%, p < 0.01) and a significant increase in DTE ratio (2.04%; 95% CI = 0.71 to 3.36, p < 0.01). Compared with the baseline trends in the pre-CDPR period, the per capita HE in the post-CDPR period decreased by ¥301.9 per month (95% CI = − 394.8 to − 208.9, p < 0.001), DE ratio decreased at a rate of 0.32% per month (95% CI:− 0.55 to − 0.08%, p < 0.05) and the DTE ratio increased at a rate of 0.25% per month (95% CI = 0.04 to 0.46%, p < 0.01). In the entire study period, no statistically significant difference in imbursement ratio was observed (Fig. 1). The ITSA results of ITSA of each outcome variable were reported in additional file 2 Table S1 and S2.
ITSA results of medical utilisation in different hospitals
In the pre-CDPR period and the start of the CDPR, no statistically significant difference was found in the number of inpatients in different hospitals. However, compared with the difference between the pre- and post-CDPR slopes, significant reductions were found in the number of inpatients in secondary (− 458 per month, 95% CI = − 643 to − 272, p < 0.001) and tertiary (− 257 per month, 95% CI = − 510 to − 4, p < 0.05) hospitals. No significant difference was found in the number of inpatients in primary hospitals (Fig. 2). The ITSA results of medical utilisation in different hospitals were reported in additional file 2 Table S3.
ITSA results of government financial reimbursement in different hospitals
During the entire study period, the per capita BMI reimbursement in primary hospitals remained stable and had no significant change. The per capita BMI reimbursement in secondary hospitals presented a trend of growth (¥120.3 per month, 95% CI = 48.1 to 192.5, p < 0.01) in the pre-CDPR period and sharply declined (¥ − 1613.4 per month, 95% CI = − 2926.6 to − 300.1, p < 0.05) in the start of the CDPR implementation, but the change in the pre- and post-CDPR slopes had no significant difference (p = 0.378). The per capita BMI reimbursement in tertiary hospitals had an increase of ¥122.8 per month (95% CI = 24.8 to 220.8, p < 0.05) in the pre-CDPR period and a sharp decline (¥ − 1327.9 per month; 95% CI = − 2115.2 to − 540.5, p < 0.01) in the period immediately following reform. Moreover, the change in the trends of the pre- and post-CDPR slopes had a statistically significant decrease (¥ − 254.7 per month, 95% CI = − 376.0 to − 133.5, p < 0.001) (Fig. 3). The ITSA results of BMI reimbursement in different hospitals were reported in additional file 1 Table S4.
Since the CDPR, our study shows that the per capita HE presents an expected downward trend, in which the DE share gradually decreased and the DTE share increased accordingly. Moreover, the overall utilisation of medical service was a decrease of 9340 person-times compared with that before the reform. The government’s financial reimbursement for inpatients has changed.
Our finding corroborated previous research showing the CDPR implementation effectively controls the rapid growth of HE and adjusts its structure [29, 37, 38]. These previous studies focused more on the impact of CDPR on medical expenses than on BMI reimbursement or medical service utilisation, or both. Through in-depth analysis of the changing trend of BMI reimbursement and medical service utilisation in different hospitals, we found that the decrease of medical service utilisation was mainly focused on that in large hospitals such as secondary and tertiary hospitals, and the main change of government financial reimbursement was a decline in the BMI reimbursement level for inpatients in tertiary hospitals. Among the few studies that comprehensively analyzed the impacts of CDPR on HE, BMI reimbursement and medical service utilization, a study  from high-income region found that the CDPR increased the BMI reimbursement level, thus stimulating inpatients to over-utilize medical service in large hospitals. Another study  from a region with similar economic development to this study found that the CDPR had raised the BMI reimbursement level in tertiary hospitals. The above studies used descriptive methods to analyze the changing trend of BMI reimbursement and medical service utilisation, which could not exclude the possibility of an upward or downward trend before the intervention. Therefore, our study complements the evidence on the impact of CDPR on the BMI reimbursement and medical service utilisation.
A reduction of HE could stimulate more patients to release the needs for hospitalization services. This study found that after the reform, the utilisation of medical services not only didn’t increase, but reduced utilisation of medical service in secondary and tertiary hospitals didn’t trigger an influx of patients into primary hospitals. Under the influence of many factors such as economic development and medical resources, the medical service utilisation in western China has been lower than that in other regions . This finding implies a further deterioration in the low utilisation of medical service in this region. The result should be related to the BMI payment. In addition to adjusting reimbursement, the reform of BMI payment launched the global-budget payment system and payment by the type of disease as part of the CDPR. These two payment methods, by setting each hospital’s annual budget and the payment criteria for each common disease, and adopting the principle of surplus retention and non-compensation of overspending, stimulated each hospital to actively control the increase in the overall and personal medical expenses and reduce inappropriate admission [40,41,42]. However, when deciding on admission, doctors may prefer to choose patients with no comorbidities, complications or unserious illness to avoid exceeding the annual budget apportioned to the department and the payment limit for the diseases . Therefore, the reduction of inpatients should include both those who are improperly admitted and those with sevious illness who need to be admitted but are refused. This finding shows that the implementation of the CDPR reduces the medical service utilisation of patients with severe diseases and lessens the chances of their access to timely and effective treatment.
The decrease of BMI reimbursement level in tertiary hospitals after the CDPR demonstrates that Shihezi government has reduced the compensation for patients with critical and severe diseases. The medical service function in tertiary hospitals in China is to rescue, diagnose and treat patients with critical and severe illness . Thus, the condition of inpatients who meet the admission standards of tertiary hospitals should be more serious than that in other hospitals. BMI reimbursement is designed to provide financial risk protection for patients against poverty caused by disease . This finding demonstrates that after the CDPR, the out-of-pocket medical expenses of inpatients in tertiary hospitals are increasing. From the patients’ perspective, this not only increases the financial burden on inpatients with relatively severe and complex diseases, but may also be a key factor that affects access to medical services for patients with poverty who meet the criteria for hospital stay in tertiary hospitals.
There are several limitations observed in this study. A major limitation is that the accessibility of data limits comparative analysis with other representative cities to evaluate the effectiveness of the CDPR more comprehensively. A long-term multiregional evaluation is needed to evaluate the overall effect of the reform objectively and comprehensively. A report on the similarities and differences between the effects and objectives of CDPR in a city from Western China is provided as a basis for future studies. The difference in the severity of inpatients’ illness before and after the reform cannot be determined due to the limited data. Thus, the influence of this confounding factor on HE cannot be ruled out. At present, the payment model of disease-related groups for inpatients’ care is still in the pilot stage . For further studies, the combination index of case in the payment method can be used to reflect the severity of the disease, the complexity of diagnosis and treatment methods, the amount of resource consumption, and evaluate the effectiveness of the reform more scientifically and objectively. Finally, the models in this study assume a linear trend of outcome variables before and after the intervention. In fact, the possibility of non-linear trends also exists. Although some models, such as Box-Jenkins models, may be used to analyze non-linear trends, they are less useful in examining changes in trend occurring at defined time points . In this study, 12 data points before and after the CDPR and more than 100 observations per data point were collected, which can provide the robust estimates of change in level and trend for outcomes .
Although the study has limitations, our findings provide important implications for the health development of CDPR in regions with weak economic development. The reduction of medical service utilisation and the diminution of financial compensation for patients with critical and severe implicates that the reform of the medical insurance payment system in the CDPR only focuses on the control of medical expenses and the adjustment of the structure of DE and DTE, but ignores the correct guidance of medical service utilisation and the financial risk protection of patient. It illustrates that synchronising the suite of policies is affected by the fragmented governance of medical care, medicine and medical insurance. Therefore, when formulating the specific measures of the CDPR, local governments need to adapt to the local conditions and give full play to the incentive and compensation mechanisms of medical insurance, rather than mechanical control medical expenses and restructuring them.
Overall, the CDPR has decreased the per capita HE and per capita DE amongst the inpatients of Shihezi significantly and has a positive role in increasing DTE. Results demonstrate that the CDPR controls the increase in medical expenses and reasonably adjusts its structure. However, the CDPR reduces the medical service utilisation of inpatients in secondary and tertiary hospitals and sharply declines the government financial reimbursement for inpatients in tertiary hospitals. The former may affect the timely and effective treatment for patients with serious diseases, whereas the latter increases the financial burden on inpatients from tertiary hospitals and may hinder access to medical services for patients who meet the criteria for admission to tertiary hospitals. These findings will affect the health equity of population in this aging city, eventually affecting the process of reform.
Availability of data and materials
The datasets generated and/or analyzed during the current study are not publicly available due to the data ownership belongs to the Social Insurance Administration Bureau in Shihezi City. Interested parties could contact the Social Insurance Administration Bureau in Shihezi City to request access to data.
basic medical insurance
comprehensive drug price reform;
diagnosis and treatment expense
interrupted time series analysis
urban employee medical insurance
urban and rural resident medical insurance
Xinjiang Production and Construction Corps.
Califf RM, Slavitt A. Lowering cost and increasing access to drugs without jeopardizing innovation. JAMA. 2019;321(16):1571–3.
Parekh N, McClellan M, Shrank WH. Payment reform, medication use, and costs: can we afford to leave out drugs? J Gen Intern Med. 2019;34(03):473–6.
The Global Use of Medicines in 2019 and Outlook to 2013. 2019. Available from:https://www.iqvia.com/en/institute/reports/the-global-use-of-medicine-in-2019-and-outlook-to-2023. [cited 2019 Dec 2].
Gronde TVD, Uyl-de Groot CA, Pieters T. Addressing the challenge of high-priced prescription drugs in the era of precision medicine: a systematic review of drug life cycles, therapeutic drug markets and regulatory frameworks. PLoS One. 2017;12(08):e0182613.
Humphries B, Xie F. Canada's amendment to patented drug price regulation: a prescription for global drug cost control? Jama. 2019;321(16):1565–6.
Webster P. Considering transparency and value for fairer drug prices. Can Med Assoc J. 2018;190(1):E30–1.
Ben-Aharon O, Shavit O, Magnezi R. Does drug price-regulation affect healthcare expenditures? Eur J Health Econ. 2017;18(07):859–67.
Joyce G, Henkhaus LE, Gascue L, Zissimopoulos J. Generic drug price hikes and out-of-pocket spending for medicare beneficiaries. Health Aff (Millwood). 2018;37(10):1578–86.
Kwon H, Bae S, Choi S, Park S, Lee E, Park S, Kim J. Easy cuts, easy rebound: drug expenditures with massive price cuts in Korea. Health policy (Amsterdam). 2019;123(04):388–92.
Xingang F, Jun L, Huimin S. “Drug rebate” is the crux of the problem of health care reform in China. Med Philos. 2015;36(06):75–7.
Li Hui. Three questions about the reform of drug price in public hospitals. 2016. Available from: https://epaper.gmw.cn/gmrb/html/2016-08/25/nw. D110000gmrb_20160825_ 1–15.htm. [cited 2019 Dec 2].
Yu W. Exploration of implementation methods of drug price reform in China. China Pharmacy. 2015;26(25):3466–9.
Dezhi Y, Guang S, Minxia W, Xiaoxiao T. Transformation of the long- term mechanism on the prevention of corruption in the procurement, prescription and dispensing of the pharmaceuticals in health establishment in China: abandoning the compensation system for the medial cost through drug- selling profits. Chinese Health Econ. 2008;02:14–6.
Weng H, Shuguang S. Can social health insurance balance health protection and cost control while insuring “minor illness”. Insurance Stud. 2018;11:93–106.
General Office of the State Council of the P.P. Chnia. Guidance opinions on the pilot of the comprehensive reform of urban public hospitals. 2015. Available from: http://www.gov.cn/zhengce/content/2015-05/17/content_9776.htm. [cited 2019 Dec 2].
Tinjian Z, Yuanyuan S. Perfecting the hierarchical diagnosis and treatment system: enhancing grass-roots, boosting doctor average level. Res Exploration Lab. 2019;38(05):241–4.
Long S. Analysis on tiered diagnosis and treatment policy in China from perspective of universal health coverage. Med Soc. 2018;31(11):5–7.
State Council of the P.R. China. Guiding opinions on further deepening reform for payment methods of BMI. 2017. Available from: http://www.gov.cn/zhengce/content/2017-06/28/content_5206315.htm. [cited 2019 Dec 2].
State Council of the P.R. China. Opinions on promoting the reform of medical service prices. 2017. Available from: http://www.gov.cn/gongbao/content/2017/content_5174533.htm. [cited 2019 Dec 2].
Youcai Y, Yaoweng C. Study on the interaction mechanism between economic growth speed and quality level in eastern, central and western China: based on the relationship perspective of financial resource allocation efficiency and total factor productively. Shandong Soc Sci. 2019;05:118–24.
Yang L, Elim M, Yanan G, Chen L, Shixue L. Analysis on the level of financing, structure and variation trend of total health expenditure from 1995 to 2011 in Xinjiang. Chinese J Hosp Adm. 2015;31(01):33–6.
Jiaming L, Xiaoju L, Weidong X, Jingxia T, Jun R. The results and analysis of the total health expenditure in Shihezi reclamation area of the eighth division of Xinjiang production and construction corps in 2011. Soft Sci Health. 2014;28(07):428–30.
National Bureau of Statistics of China. China statistical yearbook in 2016. 2016. Available from: http://www.stats.gov.cn/tjsj/ndsj/2016/indexch.htm. [cited 2019 Dec 2].
Qin Y, Xinhui Z, Xinrong W. Study on the establishment of long-term nursing insurance in Shihezi City. Xinjiang Med J. 2018;48(01):114–6 121.
Shifa X, Yannan Z, Xianzhi F, Fei X, Changqing S. A comparative analysis of the equity of medical service utilization among Chinese residents based on the centralized index. Chinese J Health Statictics. 2019;36(04):595–7 600.
National Health and Family Planning Commission of the P.R. China. The notice on Comprehensive Reform of Public Hospitals. 2017. Available from: http://www.nhc.gov.cn/tigs/s3581/201704/0563e06eff4441ffa9772dc30b487848.shtml. [cited 2019 Dec 2].
Central People’s Government of the P.R. China. Healthcare reform brings a real sense of acquisition. 2017. Available from: http://www.gov.cn/xinwen/2017-09/23/content_5227000.htm. [cited 2019 Dec 2].
Hong Z, Lirong Y, Lei Z, Bing L, Yan L, Xiujuan W. Research on the influence of medical service price reform on medical insurance fund and residents’ medical burden in public hospitals of Qinghai. Chinese Health Econ. 2018;37(09):37–40.
Fu H, Li L, Yip W. Intended and unintended impacts of price changes for drugs and medical services: evidence from China. Soc Sci Med. 2018;211:114–22.
Ping L, Bao L. The dynamic adjustment mechanism of medical service price. Health Econ Res. 2019;36(08):20–3.
Jing P, Yanhui W. Comparative analysis of drug price levels in 23 provinces and cities in China under the background of regional differentiation. Health Econ Res. 2019;36(02):49–52.
Yuhang L. Effectiveness of compensation mechanism reform on demanders’ perspective in Hainan Provincehang. Chinese Hosp Manag. 2019;39(02):28–30.
Taoyu L, Liping J, Changmin T, Pengqian F. Influence of comprehensive medicine price reform on hospitalization expenses: an analysis with quantile regression model. China J Public Health. 2019:1–4.
Central people’s government of the P.R. China. All public hospitals in Xinjiang have canceled drug markup expenses and received a special subsidy of 500 million yuan. 2017. Available from: http://www.gov.cn/xinwen/2017-09/01/content_5222050.htm. [cited 2019 Dec 2].
Penfold RB, Zhang F. Use of interrupted time series analysis in evaluating health care quality improvements. Acad Pediatr. 2013;13S(6):S38–44.
Linden A. Conducting interrupted time-series analysis for single- and multiple-group comparisons. Stata J. 2015;15(2):480–500.
Fu H, Li L, Li M, Yang C, Hsiao W. An evaluation of systemic reforms of public hospitals: the Sanming model in China. Health Policy Plan. 2017;32(8):1135–45.
Chuanchuan Z, Xiaoyan L, Strauss J, Yaohui Z. Health insurance and health care among the mid- aged and older Chinese: evidence from the national baseline survey of CHARLS. Health Econ. 2017;26(4):431–49.
Winnie Y, Hongqiao F, Angela TC, Tiemin Z, Weiyan J, Roman X, et al. 10 years of health-care reform in China: progress and gaps in universal health coverage. Lancet. 2019;394(10204):1192–204.
Xiaoju L, Lu M, Mei Z, Bin W. Analysis of the influence of the total prepayment system reform on the hospitalization of employee medical insurance patients. Health Econ Res. 2018;11:46–9.
Nian C, Zaoli W, Xiaoguang F, Daping S, Jing R, Donghui Z. AnaIysis of the pricing mechanisms of provider payment system reforms under medical insurance. Chinese Health Econ. 2017;36(09):28–31.
Zhishui C, Jiahua L, Yi L, Hui W. Evaluation of the effects of global budget policy on hospitalization expenditure by matching difference-in-difference model. Chinese Hosp Manag. 2018;38(04):53–5.
Baosong C, Na G, Li C, Qiong W, Dawei Z. Analysis of the impact of compensation mechanism reform on medical service utilization of county-level public hospital. Chinese J Soc Med. 2019;36(03):299–301.
State Council of the P.R. China. Guiding opinions on promoting the construction of hierarchical diagnosis and treatment system. 2015. Available from: http://www.gov.cn/zhengce/content/2015-09/11/content_10158.htm. [cited 2019 Dec 2].
La Forgia A, Burns LR. Health insurance in China. In: Burns LR, Liu GG, editors. China’s healthcare system and reform. Cambridge: Cambridge University Press; 2017.
Yu X, Shangzhi H, Na L, Lei M, Cuiping W, Yashuang L. Applicable conditions and domestic pilot of disease diagnosed related groups based on economics. Chinese Hosp Manag. 2019;39(02):65–7.
Ramsey AT, Maki J, Prusaczyk B, Yan Y, Wang J, Lobb R. Using segmented regression analysis of interrupted time series data to assess colonoscopy quality outcomes of a web-enhanced implementation toolkit to support evidence-based practices for bowel preparation: a study protocol. Implement Sci. 2015;10:85.
Jandoc R, Burden AM, Mamdani M, Levesque LE, Cadarette SM. Interrupted time series analysis in drug utilization research is increasing: systematic review and recommendations. J Clin Epidemiol. 2015;68(08):950–6.
We thank the staff of the Social Insurance Administration Bureau in Shihezi City for providing us access to the database of basic medical insurance.
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Ethics approval and consent to participate
Consent for publication
The authors declare no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
The proportion of per capita DE in per capita HE in China, 2007–2017.
ITSA results of medical expenses. Table S2. ITSA results of the distribution of medical expense. Table S3. ITSA results of medical utilisation in different hospitals. Table S4. ITSA results of BMI reimbursement in different hospitals.
About this article
Cite this article
Lin, T., Wu, Z., Liu, M. et al. Evaluation of the effectiveness of comprehensive drug price reform: a case study from Shihezi city in Western China. Int J Equity Health 19, 133 (2020). https://doi.org/10.1186/s12939-020-01246-9
- Comprehensive drug price reform
- Medical expense
- Medical service utilisation
- Basic medical insurance
- Interrupted time-series