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Area deprivation and its association with health in a cross-sectional study: are the results biased by recent migration?
International Journal for Equity in Health volume 6, Article number: 10 (2007)
The association between area deprivation and health has mostly been examined in cross-sectional studies or prospective studies with short follow-up. These studies have rarely taken migration into account. This is a possible source of misclassification of exposure, i.e. an unknown number of study participants are attributed an exposure of area deprivation that they may have experienced too short for it to have any influence. The aim of this article was to examine to what extent associations between area deprivation and health outcomes were biased by recent migration.
Based on data from the Oslo Health Study, a cross-sectional study conducted in 2000 in Oslo, Norway, we used six health outcomes (self rated health, mental health, coronary heart disease, chronic obstructive pulmonary disease, smoking and exercise) and considered migration nine years prior to the study conduct. Migration into Oslo, between the areas of Oslo, and the changes in area deprivation during the period were taken into account. Associations were investigated by multilevel logistic regression analyses.
After adjustment for individual socio-demographic variables we found significant associations between area deprivation and all health outcomes. Accounting for migration into Oslo and between areas of Oslo did not change these associations much. However, the people who migrated into Oslo were younger and had lower prevalences of unfavourable health outcomes than those who were already living in Oslo. But since they were evenly distributed across the area deprivation quintiles, they had little influence on the associations between area deprivation and health. Evidence of selective migration within Oslo was weak, as both moving up and down in the deprivation hierarchy was associated with significantly worse health than not moving.
We have documented significant associations between area deprivation and health outcomes in Oslo after adjustment for socio-demographic variables in a cross-sectional study. These associations were weakly biased by recent migration. From our results it still appears that migration prior to study conduct may be relevant to investigate even within a relatively short period of time, whereas changes in area deprivation during such a period is of limited interest.
In studies of area effects on health, misclassification of exposure due to recent migration may be a problem. Area effects on health has mostly been examined in cross-sectional studies or prospective studies with short follow-up, but migration is rarely taken into account. Studies that do not take length of residence into account may give spurious area effects on health, because individuals may be assigned an area exposure that they may have experienced too short for it to have any effect , and their current health may instead show the possible effects of their previous areas of residence , e.g. as in Blakely et al, who suggested that for people aged 45 years and older, income inequality up to 15 years previously may be more strongly associated with self rated health than income inequality measured contemporaneously. A cross-sectional design appears inappropriate when thinking about socially and biologically plausible causal pathways by which areas might influence health .
In a cross-sectional study of a city population several types of migration may bias the results. Firstly, the aspect of selective migration, i.e. people in poor (or good) health moving to areas of poor (or good) status. Secondly, the aspect of health-promoting or health-damaging effects of the act of moving itself. For example, Kahlmeier et al found an increased wellbeing of movers who had moved into areas with improved environmental housing quality. On the other hand, some people may have difficulties in adapting to a new area, e.g. in creating connections with neighbours, which may be detrimental to health. The common denominator in dealing with these two types of migration is the requirement for longitudinal health data. Therefore, these issues will remain potential sources of bias in cross-sectional studies.
Still, some aspects of migration may be dealt with even in cross-sectional studies, in which we can imagine two types of migration prior to the study conduct: migration into the city and within the city. Both need to be considered. This can be done by using retrospective linkage of residence data. But because some people tend to have rather frequent changes in residence, we believe it is important to have retrospective annual data of residence in order to capture the true exposure for the study participants. Furthermore, areas themselves may change over time, implying that people may experience different levels of area deprivation without moving at all. Boyle et al addressed these problems using a selection of people from the ONS Longitudinal Study for England and Wales that had not moved between 1971 and 1991, and who were living in non-deprived households throughout the period. The authors found that changes in deprivation in the residential area had a demonstrable effect on morbidity. The study also showed a clear gradient for morbidity which demonstrated that people living in areas which remained most deprived throughout the period had the most morbidity, and people living in areas which remained least deprived had the lowest morbidity. This is in accordance with a number of studies measuring area effects cross-sectionally with a variety of different measures; self rated health [7–12], mental health [13, 14], coronary heart disease , respiratory disease [8, 16, 17], daily smoking [8, 17–22] and exercise [18, 23, 24], after adjusting for individual characteristics. Significant associations between areas and health have been widely documented , but potential bias from migration is rarely investigated. Some studies with large study populations have more or less eliminated migration bias by restricting their analyses to individuals who have resided in a given area over a relatively long period , whereas other studies with smaller populations have adjusted for number of years in current area of living . Most studies neglect the aspect of migration, presumably in lack of data.
The aim of this study was to investigate to what extent cross-sectional analyses of the associations between area deprivation and health (self rated health, mental health, coronary heart disease, chronic obstructive pulmonary disease, smoking and exercise) are biased by recent migration. We specifically tested whether: 1) the associations between area deprivation and health were different if we removed those participants that had recently migrated into Oslo (i.e. testing bias from migration into Oslo), and 2) whether the associations between area deprivation and health were different if those who had lived in Oslo in the period 1992–2000 were assigned a deprivation measure taking all years of residence into account, instead of only year 2000 (i.e. bias from migration within Oslo).
Area deprivation is a frequently used concept but has no singular definition . Anderson et al claim that area deprivation "may summarise an area's potential for health risk from ecological concentration of poverty, unemployment, economic disinvestment, and social disorganisation". Our definition of the concept is much in line with this. We define area deprivation as "the clustering of people with limited possibilities for choosing destination of residence". Areas with a high level of socioeconomic disadvantage may also be disadvantaged with respect to other area characteristics in ways that influence health independently of the socioeconomic characteristics of the people living in such areas . Massey  claims that to the extent disadvantaged individuals are concentrated in geographically defined areas, disadvantage becomes a characteristic of the areas too. Such disadvantage may take two forms ; physical disorder (such as abandoned buildings, noise, graffiti, vandalism, filth and disrepair) and social disorder (such as crime, loitering, public drinking or drug use, conflicts and indifference). Both types of disorder lead to unattractiveness in the housing market. Structural factors through the employment and housing market offer limited possibilities for withdrawal from the area for some people , who will have few options to escape from unfavourable conditions that have been found to be associated with health, e.g. poor housing quality [5, 30–32] and poor physical quality of the residential environment [5, 11, 31, 33, 34].
A Norwegian study from 1994 demonstrated how certain economically disadvantaged inner-city areas of Oslo were characterised by three specific groups . Firstly, a large clustering of people with several lifestyle disadvantages (e.g. unemployment, poor health). Secondly, a large group of people who had recently moved in, but who did not regard their destination of arrival as a desired area to move to. Furthermore, within these areas the largest percentage of people in Oslo who wanted to move to another area was found. And thirdly, a large group of young people, who would leave the area after a few years, regarding the area as an interim destination. In reference to the housing market; because the value of each home depends on the quality of the neighbourhood, owners have a substantial personal interest in preserving and improving it, compared to short-time renters . Therefore, the extent to which young people exploit cheap tenure possibilities in low price areas, leading to high area turnover, may decrease social cohesion and induce more social disorganisation [7, 17]. Overall, we argue that individual socioeconomic disadvantage restricts freedom of choosing where to live, and that those possibilities that do exist are characterized by physical and social disorder. Some support of this view was found by Stafford and Marmot  who demonstrated that perceived neighbourhood problems (e.g. lack of facilities, noise) and perceived housing problems mediated the association between area deprivation and poor self rated health.
Study population and participants
Data were obtained from the Oslo Health Study (HUBRO), a joint collaboration between the Oslo City Council, the University of Oslo, and the Norwegian Institute of Public Health in 2000–2001. A total of 40 888 persons in five age cohorts were invited to participate. Participation rate was 46% . We included those aged 30 (participation rate 36.1%), 40 (participation rate 43.7%), 45 (participation rate 46.5%) and 60 (participation rate 55.4%). This left us with a total population of 14 608 persons. These were divided into three groups: Stayers (those who lived in the same area in Oslo in all years, n = 6 072), migrants (those who lived in Oslo in all years, but moved between areas, n = 4 995) and in-migrants (those who moved into Oslo during 1992–2000, n = 3 541).
Independent individual variables
Age, sex, marital status (married/registered partner; unmarried; and divorced, separated, widow/widower and other marital forms), education (academic college or university education, and lower educational forms), and employment status (full-time employed, part-time employed, and not working) were self-reported. Income was total taxable income of 1999 (linked from Statistics Norway), quintilised with the first quintile representing the highest incomes. We included this many measures of individual socioeconomic position in order to reduce the likelihood that the associations between area deprivation and health were attributable to unmeasured or poorly measured confounding by individual factors [23, 25, 37].
Independent variable: Area deprivation
Oslo is the capital city of Norway and the country's largest city. At the time of the study, the city was divided into 25 administrative areas with a total population of 503 720. Area deprivation was a composite index of five items: 1) percentage of population affected by social security benefits (i.e. both direct receivers and any family members), 2) percentage of unemployed (age 16–66), 3) percentage receiving disability pension (age 16–66), 4) percentage with no academic college or university education (age 16–66), and 5) average taxable income in the area. The items were chosen in order to reflect the clustering of people within an area with anticipated limited possibilities of choosing destination of residence, particularly those with limited exit options from current area of living. Across all five indicators, the areas were quintilised. A composite rank score from 5 (least deprived) to 25 (most deprived) was calculated and quintilised for the analyses. This was repeated for all years back to 1992, i.e. we had annual area deprivation indexes throughout the period 1992–2000. Data were provided by the Oslo City Council.
Dependent variables: Health outcomes
Self rated health (SRH) was derived from the question: "How would you describe your present state of health (poor, not very good, good, very good)", dichotomised into poor/not very good and good/very good. Mental health (HSCL) was measured by The HSCL-10 consisting of 10 items on a 4-point scale . Cut-off was set at 1.85 (< 1.85 indicating good mental health, and > 1.85 indicating poor mental health), which has been found equivalent to the conventional cut-off point at 1.75 for HSCL-25, and is a validated measure of mental health . Coronary heart disease (CHD) was measured by The Rose Questionnaire of angina pectoris . Chronic obstructive pulmonary disease (COPD) was assessed by a modified version of the Medical Research Council's questionnaire with three items . Smoking was assessed by the question "Have you smoked or do you smoke?" which has been shown to produce relatively reliable information about smoking habits . Former and never smokers were collapsed into one group, contrasted to current smokers. Exercise was measured by the question "What kind of physical activity have you undertaken in the course of the past year? Estimate a weekly average for the year (hard physical activity, you sweat or feel out of breath)". The variable was dichotomised into no exercise at all and have exercised. Measuring exercise by self-reported data on number of occasions or time spent on such activities is commonly used [18, 24, 43, 44]. Missing values on the health outcomes were 132 for SRH, 579 for HSCL, 111 for CHD, 1 940 for COPD, 107 for current smoking and 924 for no exercise. Data on COPD was obtained from an additional questionnaire that had a much lower response rate than the main questionnaire in the Oslo Health Study. Hence the large number of missing values for COPD.
We specified three binomial multilevel logistic regression models, estimating the parameters by the penalised quasilikelihood method. Analyses were conducted for all health outcomes, in which we measured the association between area deprivation and health after adjusting for individual variables. Model 1 included all HUBRO-participants, i.e. a traditional cross-sectional analysis. In model 2 we removed the in-migrants, and in model 3 area deprivation was measured as an average of all areas of residence during the period 1992–2000 for those who had lived in Oslo in all years, i.e. a so-called multiple membership design . Between-area variance was calculated, indicating the unexplained variance in the outcome of interest in the 25 areas. The results of the regression analyses are presented as odds ratios (95% confidence intervals) with test for trend estimates for area deprivation, which represent the odds ratios when the are deprivation quintiles are analysed as a continuous variable. Analyses were carried out using the software MLwiN (version 1.10.007) . SPSS for Windows (version 11.0) was used to perform χ2 tests. SAS (version 9.1) was used to perform Cochran-Armitage trend tests.
The Oslo Health Study had a large proportion of missing respondents (54%). Compared to the invited population, the following subgroups were under-represented : males, the youngest age-group, unmarried and separated/divorced, those not born in Norway, inner city dwellers, those with unknown or lower secondary education, low income groups, and receivers of disability benefits. But self-selection by socio-demographic background did not influence prevalence estimates in SRH, HSCL and smoking to any degree . To what extent CHD, COPD and exercise were influenced, we cannot tell. Furthermore, 12.3% in our sample had one or more missing values on the independent variables (Table 1). Those with one or more missing values were worse off in terms of both socio-demographic variables and health outcomes than those with no missing values (figures not shown). In order to avoid bias from exclusion of participants with missing values, we included them as separate missing categories in the analyses.
Ethics and approvals
All participants of the Oslo Health Study gave their written consent. The Norwegian Data Inspectorate approved the study, the Regional Committee for Medical Research Ethics evaluated it, and it was conducted in full accordance with the World Medical Association Declaration of Helsinki.
The 25 administrative areas of Oslo were ranked according to the area deprivation index in 1992 and 2000 (Table 2), and the rankings were almost completely stable. There was a clear relationship between area deprivation and unfavourable health outcomes, indicating strong differences in health between the areas of Oslo. For example, the prevalence of poor SRH varied between 12.6% (Ullern, deprivation category 1) and 32.9% (Romsaas, deprivation category 5), indicating almost 2.4 times as high prevalence in the area with the highest compared to the lowest prevalence. This proportion was 2.6 in HSCL, 5.3 in CHD, 4.9 in COPD, 2.4 in current smoking and 1.7 in no exercise.
Table 3 describes the characteristics of the five items forming the area deprivation index. Average taxable income numbers are somewhat biased because of changes in the tax legislation during the 1990s when legal options for reducing tax liability were reduced. Levels of people affected by social security benefits were slightly reduced between 1992 and 2000, while the percentages of people with higher education increased. Distribution of the items across areas was rather stable (as seen by standard deviation, range and interquartile range). Exceptions were income (which must be treated with much caution) and percentage of people affected by social security benefits for which the standard deviation and range decreased.
In our sample, 75.8% had lived in Oslo in the period 1992–2000 and 24.2% were in-migrants, i.e. moving into Oslo during the same period (Table 1). χ2 tests showed that the in-migrants were significantly younger, higher educated, more often unmarried and had lower income than those living in Oslo (p < .0001, figures not shown). In-migrants were significantly better off in all health outcomes, although differences in prevalences were small (p < .0001 for SRH, smoking and no exercise, p < .01 for CHD, p < .05 for HSCL and COPD). The groups differed somewhat by area deprivation (p < .0001), but none of the groups could in general be claimed to live in more deprived areas than the other, i.e. no significant linear association was found. Cochran-Armitage trend tests revealed that the social gradients in health according to area deprivation was significant for both groups (p < .001), except COPD for in-migrants (p > .05) (figures not shown). The prevalences were about twice as high in the most deprived compared to the least deprived areas for both groups, except for smoking and no exercise where differences were somewhat smaller.
Table 4 shows a matrix of movings within deprivation categories for stayers and migrants, i.e. those who had lived in Oslo since 1992. 54.8% resided in the same deprivation category in both 1992 and 2000, 22% had moved down in the deprivation hierarchy, while 23% had moved up. Thus 45.2% did not live in an area in the same deprivation category in 2000 as they did nine years before, and in addition, 24.2% of all study participants had migrated into Oslo. This implies that 58.4% of the HUBRO-participants are potentially being attributed an area deprivation category that they have only recently been exposed to if migration is not accounted for.
Table 5 shows differences between stayers and migrants (i.e. moved up or down in the deprivation hierarchy in the period 1992–2000). For all variables (and within all categories) there is roughly a '25-50-25' distribution, i.e. 25% moving down, 50% being stable and 25% moving up. By restricting the figures to those who had moved within Oslo, we found that those who moved up were significantly older, had higher education and income, and better self rated health (but did not differ in any other health outcomes).
In a multivariate logistic regression analysis, after adjustment for age, sex, marital status, education, employment status and income, we found that for all health outcomes, those who had moved downwards had significantly worse health compared to the stayers (Table 6). But this was also the case for those who had moved upwards, although the associations were weaker. When the stayers were excluded, there were no significant differences in health between those who moved up and those who moved down. Thus, moving, regardless of direction, was associated with worse health compared to not moving.
After adjustment for age and sex, there were significant area variances in health outcomes (Table 7), both when examining all HUBRO-participants in 2000 (model 1) and when excluding in-migrants in 2000 (model 2). Area level variances did not vary much between the two models. After adjustment for socio-demographic variables, area variance changed to non-significant for HSCL, CHD and COPD, but significant area variance remained for SRH, smoking and no exercise, meaning that differences between areas in these outcomes were not fully explained by the composition of the people residing there.
In multilevel logistic regression analyses investigating the associations between area deprivation and health after adjustment for socio-demographic variables, we first included all participants, i.e. a traditional cross-sectional study (Table 8). The respondents with missing values on any independent variables were included as separate missing categories. Differences in the distributions of independent variables (including health outcomes) by missing/no missing were tested with χ2 tests (figures not shown), and showed that those with missing values differed on all variables (p < .0001) except sex and COPD (p > .05). The missing group had lower educational attainment, was more often unmarried, more often unemployed, and had lower income. 43.9% in the missing group, compared to 17.4% of those with no missing, fell in the lowest income category, and 8.8% and 21.2% respectively were in the highest income category. 25.2% of the missing group was in the most deprived category compared to 18.8% of the included, and 19.3% and 22.6% respectively were in the least deprived category. 33.8% in the missing group reported poor SRH compared to 20.1% in the included group, 17.6% reported poor HSCL (compared to 10.6%), 11.2% reported CHD (compared to 5.7%) and 64.4% reported that they performed no exercise (compared to 54.2%). The only outcome in which the missing group reported lower prevalence was in smoking where 23.3% of the missing group reported daily smoking compared to 28.3% among the included. In the multilevel regression analyses, missing categories were mainly associated with health outcomes (Table 8).
After adjustment for all socio-demographic variables, area deprivation was significantly associated with the health outcomes when all participants were included (Table 9). The associations were more or less clear stepwise. This pattern was marked for SRH, although the confidence intervals were wide and overlapping. Compared to living in the least deprived areas, living in the most deprived areas was associated with twice as high probability for reporting poor SRH. For HSCL, CHD, smoking and no exercise we found that the deprivation quintiles 3–5 were significantly different from the first quintile. For these health outcomes, odds ratios increased by level of area deprivation, but the overlapping confidence intervals did not make us eligible to speak of any gradients in associations. For COPD, only the most deprived areas were significantly different from the least deprived areas.
Overall, associations between area deprivation and health outcomes were rather identical when we removed in-migrants, and when all years (1992–2000) were taken into account. For SRH, associations were slightly stronger when area deprivation was measured in 1992–2000, than in 2000. So were the associations for being in the most deprived category in 1992–2000 for CHD and COPD. None of the socio-demographic variables changed much throughout the three models (figures not shown).
In Table 10, the area deprivation quintiles were collapsed into a continuous variable, showing significant test for trend estimates in area deprivation for all six health outcomes after adjustment for individual variables. Model 1 shows that area deprivation was significantly associated with all health outcomes for all HUBRO-participants in 2000. In model 2 we excluded the in-migrants, but the test for trend estimates were practically identical to model 1, and despite a reduction in the sample size, the confidence intervals had not widened much. In model 3, taking migration within Oslo during the period 1992–2000 into account, there were no substantial changes in the area deprivation trends.
This study suggests that cross-sectional studies are weakly biased by misclassification of area exposure due to recent migration (Tables 9 and 10). The strong associations between area deprivation and health outcomes that we found after adjustment for individual variables (Table 8) were not changed when we removed those study participants that had moved into Oslo during the last nine years prior to the study, or when we took all nine years of area deprivation into account for those who had lived in Oslo in all years. Contrary to our expectations, this study has shown that the associations between area deprivation and health are basically identical in analyses that do and do not take recent migration into account.
Why did we not find any substantial differences between models where all participants were included, and models where in-migrants were removed? The in-migrants constituted a very young age group, which is in line with previous studies demonstrating that young adulthood is the peak age for migration, when people tend to move into urban areas for education and employment opportunities [1, 35]. Age-standardised prevalences of health outcomes were about the same for in-migrants and those who had lived in Oslo. Because the in-migrants were evenly distributed across the area deprivation quintiles, they did not affect those estimates that would have been obtained if only those who lived in Oslo in 1992–2000 were included (Table 9, model 2).
When we compared those who had lived all years in Oslo measured according to their place of residence in year 2000 (Table 9, model 2) and residence for all nine years (Table 9, model 3) we also found weak differences. We assumed that model 3 would give a more accurate measure of area deprivation exposure due to, firstly, a longer time-span that would better take into account movings caused by recent life events such as a divorce, which is a factor shown to trigger moving . Secondly, because the changes in area deprivation during the period were taken into account, which has been proven to be important , but not so in our study due to a remarkable stability of the areas in the deprivation hierarchy (Table 2). Although there were changes during the period in the five items that constituted our composite deprivation measure, they did not change the areas' positioning in the deprivation hierarchy. Thirdly, because the possibility of misclassification of exposure was substantially reduced, as all movings within Oslo during nine years were registered. But although 45% of those who lived all years in Oslo were assigned different area deprivation categories in 1992 and 2000, most movings had been only one category up or one category down (Table 4). Hence, the average area deprivation scores over nine years, assigned to all individuals in model 3, did not differ much from the cross-sectionally assigned values in model 2 based on current residence (Table 9), illustrated by a correlation of .862 (p < .01).
We did not find significant area variance in all health outcomes after adjusting for the independent socio-demographic variables (Table 7). Yet, we found that area deprivation was significantly associated with all health outcomes. This is not a contra intuitive fact . Methodological explanations for this are discussed in detail elsewhere . In short, such findings may result from two main sources. Firstly, regarding the number of areas, the power to detect the variance components is affected by the number of groups and the number of persons per group in a different way than the power to detect the effects of a specific area level variable on an individual health outcome. Thus, a given study may have insufficient power to detect between area variance, and yet have sufficient power to detect the effects of a specific area variable , because the area variance depends more on the number of areas than on the number of people [37, 50]. Data availability confined us to use 25 areas that were big and heterogeneous and clearly not in line with the boundaries that shape the relevant environment for a specific individual health outcome . If data had allowed us to break down the areas into smaller units, we would most likely have seen a more pronounced variability between the areas because they would have become more homogeneous , as in e.g. Reijneveld et al.  where administrative areas split into smaller units gave increased area variances in health outcomes. Secondly, separating compositional from contextual effects is difficult , and if there is anything such as area contexts causally related to health, the pathways involved are likely to be complex and involve reciprocal causation and feedback loops [49, 53, 54]. There may be cross-level interaction effects present, in which the area-level impacts work through the individual-level variables and do not appear in the area-level variance . Therefore, Diez Roux  suggests that the only way to test a specific hypothesis about an area effect is to explicitly test it rather than rely on estimates of area-level variance to determine whether or not the hypothesis is worth testing.
Study strengths and limitations
The Oslo Health Study had a response rate of only 46%. There were also many missing values on our independent variables (Table 1). The representativeness of the participants in the analyses is debatable, but a highly representative sample is no longer considered essential for generalisability in etiological studies that report risk estimates rather than prevalence estimates . However, our primary aim was to compare the results of a cross-sectional study (Table 9, model 1) with the results when migration was accounted for in a quasi longitudinal design (Table 9, models 2 and 3), thus making the representativeness of the participants a subordinate issue.
The choice and size of area borders is a much discussed issue [52, 56, 57]. Administrative areas may not be ecologically meaningful or natural [25, 58–60]. The choice of areas in this study was driven by available deprivation data. The large sizes of our administrative areas (mean number of inhabitants was 20148) may have been too large to capture true associations between health and areas . According to Reijneveld et al it is a common view that smaller areas should result in a more valid or more stable measurement of area deprivation. The use of smaller areas may lead to an increase in measurement error, but small areas will at the same time be more homogeneous in terms of their socioeconomic and other important characteristics . However, some studies have found that administrative areas and smaller local areas provide similar results. Reijneveld et al used three types of area classifications for Amsterdam: neighbourhoods (mean: 7 850 inhabitants), postcode sectors (mean: 9 504) and boroughs (mean 32828), and found that health differences by area deprivation differed only slightly for the three geographical classifications, both with and without adjustment for individual level socioeconomic variables. Similarly, in a study from Montreal, Ross et al found that when 28 administrative areas were split into 118 'natural neighbourhoods', the models using administrative areas had remarkably similar results to the 'natural neighbourhoods', suggesting that administrative areas were good proxies for natural neighbourhoods.
Still, within our framework, it is possible that the heterogeneity of our areas (i.e. they may include both deprived and less deprived smaller neighbourhoods) leads to misclassification of exposure. It is of course fully possible to move from the most deprived local neighbourhood in a non-deprived area, to the least deprived local neighbourhood in a deprived area. Answering which of those areas that is in fact most deprived is complicated.
Our data did not allow us to specifically test such issues, and it remains a potential pitfall. Some recent studies have found that the association between area deprivation and health operate on a much smaller scale than that of administrative areas, by using spatial techniques with circular areas centered on the exact place of residence of individuals [61, 63, 64]. Such techniques also deal with the problem of people residing on the margins of an administrative area, for whom an assigned 'area status' may be rather artificial. Yet, despite the shortcomings of large administrative areas, significant associations were found.
Our effort of assigning area deprivation indexes for all years proved not be worthwhile as the areas did not change their deprivation status during the years. We cannot rule out the possibility that this stability was a result of our chosen deprivation indicators. If other indicators had been chosen, then there might have been strong enough changes in those indicators during the period 1992–2000 to change the areas' positioning in the deprivation hierarchy. Another weakness of the present study is that our health outcomes are self-reported with relatively simple instruments.
There are several strengths to this study. We did investigate to what extent the associations between area deprivation and health were confounded by smoking, which is a much debated issue [18, 65]. Adding smoking as an independent variable to our models, showed a strong and significant association between smoking and the health outcomes (figures not shown), but adding smoking had no impact on the associations between area deprivation and health outcomes. This has also been found in previous studies on e.g. CHD [66, 67]. Furthermore, our results were adequately controlled for confounding by socioeconomic position , and it is unlikely that incomplete adjustment for individual status is the reason why we found associations between area deprivation and health .
Although we could not find much difference between models with all participants and models where migrants were excluded, we did control for this, i.e. migration within Oslo and migration into Oslo, which is rarely done in cross-sectional studies. One aspect of migration that we could not adequately control for, was that of selective migration. Evidence from international studies are few, and with somewhat contradictory results. In a recent Dutch study, van Lenthe et al found little support of selective migration, whereas Norman et al found that over a 20-year period, migrants who moved from more to less deprived areas were healthier than migrants who moved from less to more deprived areas, implying that selective migration exaggerated the association between area deprivation and health.
Our cross-sectional design did not allow us to investigate this, but we did investigate differences in characteristics between those who moved upwards and downwards in Oslo (unfortunately, the in-migrants could not be included in this analysis, as deprivation data for areas outside of Oslo was not available). Those who moved up were older, better educated, had higher income and better self rated health compared to those who moved down (Table 5). But after adjusting for all individual variables, those who moved down could not be claimed to have worse health than those who moved up (Table 6). Interestingly, in the same regression analysis, we found that migration within Oslo, regardless of direction, was significantly associated with worse health compared to residing in the same area deprivation category. Within the limitations of a cross-sectional design, this does not lend support to the hypothesis that selective migration might account for the association between area deprivation and health.
From this study we outline one empirical and one methodological conclusion. Empirically, we have documented strong and significant associations between area deprivation and health outcomes in Oslo after adjustment for individual socio-demographic variables. Methodologically, we have demonstrated that these associations were weakly biased by recent migration, a commonly considered, but unresolved problem in cross-sectional analyses. Associations between area deprivation and health outcomes varied in a minor way between models that took recent migration into account and models that did not.
Norman P, Boyle P, Rees P: Selective migration, health and deprivation: a longitudinal analysis. Soc Sci Med. 2005, 60: 2755-2771. 10.1016/j.socscimed.2004.11.008.
Bentham G: Migration and morbidity: implications for geographical studies of disease. Soc Sci Med. 1988, 26: 49-54. 10.1016/0277-9536(88)90044-5.
Blakely TA, Kennedy BP, Glass R, Kawachi I: What is the lag time between income inequality and health status?. J Epidemiol Community Health. 2000, 54: 318-319. 10.1136/jech.54.4.318.
Macintyre S, Ellaway A, Cummins S: Place effects on health: how can we conceptualise, operationalise and measure them?. Soc Sci Med. 2002, 55: 125-139. 10.1016/S0277-9536(01)00214-3.
Kahlmeier S, Schindler C, Grize L, Braun-Fahrlander C: Perceived environmental housing quality and wellbeing of movers. J Epidemiol Community Health. 2001, 55: 708-715. 10.1136/jech.55.10.708.
Boyle P, Norman P, Rees P: Changing places. Do changes in the relative deprivation of areas influence limiting long-term illness and mortality among non-migrant people living in non-deprived households?. Soc Sci Med. 2004, 58: 2459-2471. 10.1016/j.socscimed.2003.09.011.
Robert SA: Community-level socioeconomic status effects on adult health. J Health Soc Behav. 1998, 39: 18-37. 10.2307/2676387.
Jones K, Duncan C: Individuals and their ecologies: analysing the geography of chronic illness within a multilevel modelling framework. Health Place. 1995, 1: 27-40. 10.1016/1353-8292(95)00004-6.
White IR, Blane D, Morris JN, Mourouga P: Educational attainment, deprivation-affluence and self reported health in Britain: a cross sectional study. J Epidemiol Community Health. 1999, 53: 535-541.
Ross CE, Mirowsky J: Neighborhood disadvantage, disorder, and health. J Health Soc Behav. 2001, 42: 258-276. 10.2307/3090214.
Cummins S, Stafford M, Macintyre S, Marmot M, Ellaway A: Neighbourhood environment and its association with self rated health: evidence from Scotland and England. J Epidemiol Community Health. 2005, 59: 207-213. 10.1136/jech.2003.016147.
Stafford M, Martikainen P, Lahelma E, Marmot M: Neighbourhoods and self rated health: a comparison of public sector employees in London and Helsinki. J Epidemiol Community Health. 2004, 58: 772-778. 10.1136/jech.2003.015941.
Fone DL, Dunstan F: Mental health, places and people: a multilevel analysis of economic inactivity and social deprivation. Health Place. 2006, 12: 332-344. 10.1016/j.healthplace.2005.02.002.
Galea S, Ahern J, Rudenstine S, Wallace Z, Vlahov D: Urban built environment and depression: a multilevel analysis. J Epidemiol Community Health. 2005, 59: 822-827. 10.1136/jech.2005.033084.
Diez-Roux AV, Nieto FJ, Muntaner C, Tyroler HA, Comstock GW, Shahar E, Cooper LS, Watson RL, Szklo M: Neighborhood environments and coronary heart disease: a multilevel analysis. Am J Epidemiol. 1997, 146: 48-63.
Shohaimi S, Welch A, Bingham S, Luben R, Day N, Wareham N, Khaw KT: Area deprivation predicts lung function independently of education and social class. Eur Respir J. 2004, 24: 157-161. 10.1183/09031936.04.00088303.
Smith GD, Hart C, Watt G, Hole D, Hawthorne V: Individual social class, area-based deprivation, cardiovascular disease risk factors, and mortality: the Renfrew and Paisley Study. J Epidemiol Community Health. 1998, 52: 399-405.
Ecob R, Macintyre S: Small area variations in health related behaviours; do these depend on the behaviour itself, its measurement, or on personal characteristics?. Health Place. 2000, 6: 261-274. 10.1016/S1353-8292(00)00008-3.
Ohlander E, Vikstrom M, Lindstrom M, Sundquist K: Neighbourhood non-employment and daily smoking: a population-based study of women and men in Sweden. Eur J Public Health. 2006, 16: 78-84. 10.1093/eurpub/cki047.
Sundquist J, Malmstrom M, Johansson SE: Cardiovascular risk factors and the neighbourhood environment: a multilevel analysis. Int J Epidemiol. 1999, 28: 841-845. 10.1093/ije/28.5.841.
Kleinschmidt I, Hills M, Elliott P: Smoking behaviour can be predicted by neighbourhood deprivation measures. J Epidemiol Community Health. 1995, 49 Suppl 2: S72-S77.
Shohaimi S, Luben R, Wareham N, Day N, Bingham S, Welch A, Oakes S, Khaw KT: Residential area deprivation predicts smoking habit independently of individual educational level and occupational social class. A cross sectional study in the Norfolk cohort of the European Investigation into Cancer (EPIC-Norfolk). J Epidemiol Community Health. 2003, 57: 270-276. 10.1136/jech.57.4.270.
Kavanagh AM, Goller JL, King T, Jolley D, Crawford D, Turrell G: Urban area disadvantage and physical activity: a multilevel study in Melbourne, Australia. J Epidemiol Community Health. 2005, 59: 934-940. 10.1136/jech.2005.035931.
van Lenthe FJ, Brug J, Mackenbach JP: Neighbourhood inequalities in physical inactivity: the role of neighbourhood attractiveness, proximity to local facilities and safety in the Netherlands. Soc Sci Med. 2005, 60: 763-775. 10.1016/j.socscimed.2004.06.013.
Pickett KE, Pearl M: Multilevel analyses of neighbourhood socioeconomic context and health outcomes: a critical review. J Epidemiol Community Health. 2001, 55: 111-122. 10.1136/jech.55.2.111.
Chaix B, Rosvall M, Lynch J, Merlo J: Disentangling contextual effects on cause-specific mortality in a longitudinal 23-year follow-up study: impact of population density or socioeconomic environment?. Int J Epidemiol. 2006, 35: 633-643. 10.1093/ije/dyl009.
Piro FN, Naess O, Claussen B: Physical activity among elderly people in a city population: the influence of neighbourhood level violence and self perceived safety. J Epidemiol Community Health. 2006, 60: 626-632. 10.1136/jech.2005.042697.
Anderson RT, Sorlie P, Backlund E, Johnson N, Kaplan GA: Mortality effects of community socioeconomic status. Epidemiology. 1997, 8: 42-47. 10.1097/00001648-199701000-00007.
Massey DS: The age of extremes: concentrated affluence and poverty in the twenty-first century. Demography. 1996, 33: 395-412. 10.2307/2061773.
Stafford M, Marmot M: Neighbourhood deprivation and health: does it affect us all equally?. Int J Epidemiol. 2003, 32: 357-366. 10.1093/ije/dyg084.
Stafford M, Bartley M, Mitchell R, Marmot M: Characteristics of individuals and characteristics of areas: investigating their influence on health in the Whitehall II study. Health Place. 2001, 7: 117-129. 10.1016/S1353-8292(01)00004-1.
Ellaway A, Macintyre S: Does housing tenure predict health in the UK because it exposes people to different levels of housing related hazards in the home or its surroundings?. Health Place. 1998, 4: 141-150. 10.1016/S1353-8292(98)00006-9.
Finkelstein MM, Jerrett M, Sears MR: Environmental inequality and circulatory disease mortality gradients. J Epidemiol Community Health. 2005, 59: 481-487. 10.1136/jech.2004.026203.
Wheeler BW, Ben Shlomo Y: Environmental equity, air quality, socioeconomic status, and respiratory health: a linkage analysis of routine data from the Health Survey for England. J Epidemiol Community Health. 2005, 59: 948-954. 10.1136/jech.2005.036418.
Hagen K, Djuve AB, Vogt P: Oslo: The Divided City? FAFO Report 161. 1994, Oslo, Institute for Applied Social Sciences (FAFO)
Sogaard AJ, Selmer R, Bjertness E, Thelle D: The Oslo Health Study: The impact of self-selection in a large, population-based survey. Int J Equity Health. 2004, 3: 3-10.1186/1475-9276-3-3.
Blakely TA, Woodward AJ: Ecological effects in multi-level studies. J Epidemiol Community Health. 2000, 54: 367-374. 10.1136/jech.54.5.367.
Derogatis LR, Lipman RS, Rickels K, Uhlenhuth EH, Covi L: The Hopkins Symptom Checklist (HSCL): a self-report symptom inventory. Behav Sci. 1974, 19: 1-15. 10.1002/bs.3830190102.
Strand BH, Dalgard OS, Tambs K, Rognerud M: Measuring the mental health status of the Norwegian population: a comparison of the instruments SCL-25, SCL-10, SCL-5 and MHI-5 (SF-36). Nord J Psychiatry. 2003, 57: 113-118. 10.1080/08039480310000932.
Oei HH, Vliegenthart R, Deckers JW, Hofman A, Oudkerk M, Witteman JC: The association of Rose questionnaire angina pectoris and coronary calcification in a general population: the Rotterdam Coronary Calcification Study. Ann Epidemiol. 2004, 14: 431-436. 10.1016/j.annepidem.2003.09.009.
Definition and classification of chronic bronchitis for clinical and epidemiological purposes. A report to the Medical Research Council by their Committee on the Aetiology of Chronic Bronchitis. Lancet. 1965, 1: 775-779.
Patrick DL, Cheadle A, Thompson DC, Diehr P, Koepsell T, Kinne S: The validity of self-reported smoking: a review and meta-analysis. Am J Public Health. 1994, 84: 1086-1093.
van Lenthe FJ, Martikainen P, Mackenbach JP: Neighbourhood inequalities in health and health-related behaviour: results of selective migration?. Health Place. 2007, 13: 123-137. 10.1016/j.healthplace.2005.09.013.
Ross CE: Walking, exercising, and smoking: does neighborhood matter?. Soc Sci Med. 2000, 51: 265-274. 10.1016/S0277-9536(99)00451-7.
Kawachi I, Subramanian SV: Neighbourhood influences on health. J Epidemiol Community Health. 2007, 61: 3-4. 10.1136/jech.2005.045203.
Rasbah J, Browne W, Goldstein H, Yang M, Plewis I, Healy M, Woodhouse G, Draper D, Langford I, Lewis T: A user's guide to MLwiN. Version 2.1d for use with MLwiN 1.10. 2002, London, Centre for Multilevel Modelling, Institute of Education, University of London
Verheij RA, van de Mheen HD, de Bakker DH, Groenewegen PP, Mackenbach JP: Urban-rural variations in health in The Netherlands: does selective migration play a part?. J Epidemiol Community Health. 1998, 52: 487-493.
Merlo J: Multilevel analytical approaches in social epidemiology: measures of health variation compared with traditional measures of association. J Epidemiol Community Health. 2003, 57: 550-552. 10.1136/jech.57.8.550.
Diez Roux AV: Estimating neighborhood health effects: the challenges of causal inference in a complex world. Soc Sci Med. 2004, 58: 1953-1960. 10.1016/S0277-9536(03)00414-3.
Merlo J, Chaix B, Yang M, Lynch J, Rastam L: A brief conceptual tutorial of multilevel analysis in social epidemiology: linking the statistical concept of clustering to the idea of contextual phenomenon. J Epidemiol Community Health. 2005, 59: 443-449. 10.1136/jech.2004.023473.
Fone D, Dunstan F, Lloyd K, Williams G, Watkins J, Palmer S: Does social cohesion modify the association between area income deprivation and mental health? A multilevel analysis. Int J Epidemiol. 2007, 36: 338-345. 10.1093/ije/dym004.
Reijneveld SA, Verheij RA, de Bakker DH: The impact of area deprivation on differences in health: does the choice of the geographical classification matter?. J Epidemiol Community Health. 2000, 54: 306-313. 10.1136/jech.54.4.306.
Oakes JM: The (mis)estimation of neighborhood effects: causal inference for a practicable social epidemiology. Soc Sci Med. 2004, 58: 1929-1952. 10.1016/j.socscimed.2003.08.004.
Oakes JM: Causal inference and the relevance of social epidemiology. Soc Sci Med. 2004, 58: 1969-1971. 10.1016/j.socscimed.2003.05.001.
Craig N: Exploring the generalisability of the association between income inequality and self-assessed health. Soc Sci Med. 2005, 60: 2477-2488. 10.1016/j.socscimed.2004.11.018.
Ross NA, Tremblay SS, Graham K: Neighbourhood influences on health in Montreal, Canada. Soc Sci Med. 2004, 59: 1485-1494. 10.1016/j.socscimed.2004.01.016.
Kolegard Stjarne M, Diderichsen F, Reuterwall C, Hallqvist J: Socioeconomic context in area of living and risk of myocardial infarction: results from Stockholm Heart Epidemiology Program (SHEEP). J Epidemiol Community Health. 2002, 56: 29-35. 10.1136/jech.56.1.29.
O'Campo P: Invited commentary: Advancing theory and methods for multilevel models of residential neighborhoods and health. Am J Epidemiol. 2003, 157: 9-13. 10.1093/aje/kwf171.
Diez Roux AV: Investigating neighborhood and area effects on health. Am J Public Health. 2001, 91: 1783-1789.
Mitchell R, Gleave S, Bartley M, Wiggins D, Joshi H: Do attitude and area influence health? A multilevel approach to health inequalities. Health Place. 2000, 6: 67-79. 10.1016/S1353-8292(00)00004-6.
Chaix B, Merlo J, Subramanian SV, Lynch J, Chauvin P: Comparison of a spatial perspective with the multilevel analytical approach in neighborhood studies: the case of mental and behavioral disorders due to psychoactive substance use in Malmo, Sweden, 2001. Am J Epidemiol. 2005, 162: 171-182. 10.1093/aje/kwi175.
Rezaeian M, Dunn G, St Leger S, Appleby L: Geographical epidemiology, spatial analysis and geographical information systems: a multidisciplinary glossary. J Epidemiol Community Health. 2007, 61: 98-102. 10.1136/jech.2005.043117.
Chaix B, Leyland AH, Sabel CE, Chauvin P, Rastam L, Kristersson H, Merlo J: Spatial clustering of mental disorders and associated characteristics of the neighbourhood context in Malmo, Sweden, in 2001. J Epidemiol Community Health. 2006, 60: 427-435. 10.1136/jech.2005.040360.
Propper C, Jones K, Bolster A, Burgess S, Johnston R, Sarker R: Local neighbourhood and mental health: evidence from the UK. Soc Sci Med. 2005, 61: 2065-2083. 10.1016/j.socscimed.2005.04.013.
Duncan C, Jones K, Moon G: Smoking and deprivation: are there neighbourhood effects?. Soc Sci Med. 1999, 48: 497-505. 10.1016/S0277-9536(98)00360-8.
Sundquist K, Winkleby M, Ahlen H, Johansson SE: Neighborhood socioeconomic environment and incidence of coronary heart disease: a follow-up study of 25,319 women and men in Sweden. Am J Epidemiol. 2004, 159: 655-662. 10.1093/aje/kwh096.
Diez Roux AV, Merkin SS, Arnett D, Chambless L, Massing M, Nieto FJ, Sorlie P, Szklo M, Tyroler HA, Watson RL: Neighborhood of residence and incidence of coronary heart disease. N Engl J Med. 2001, 345: 99-106. 10.1056/NEJM200107123450205.
Blakely T, Hunt D, Woodward A: Confounding by socioeconomic position remains after adjusting for neighbourhood deprivation: an example using smoking and mortality. J Epidemiol Community Health. 2004, 58: 1030-1031. 10.1136/jech.2004.019737.
The National Health Screening Service of Norway (now the Norwegian Institute of Public Health) conducted the practical part of the data collection. Statistics Norway and the Oslo City Council have provided additional data. We thank Magne Thoresen at Department of Biostatistics, University of Oslo, for performing the Cochran-Armitage trend tests in the SAS system. We also thank two anonymous referees for thorough comments and helpful suggestions.
The author(s) declare that they have no competing interests.
FNP planned the study design, performed the analyses and wrote the manuscript. BC and ØN participated in planning the study design, contributed with academic discussions and drafted and revised the manuscript. All authors read and approved the final manuscript.
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Piro, F.N., Næss, Ø. & Claussen, B. Area deprivation and its association with health in a cross-sectional study: are the results biased by recent migration?. Int J Equity Health 6, 10 (2007). https://doi.org/10.1186/1475-9276-6-10
- Chronic Obstructive Pulmonary Disease
- Self Rate Health
- Poor Self Rate Health
- Administrative Area
- Recent Migration