Table 1 Annual cost of drugs in the NRDL for sample diseases
Rare Disease | Drug | Daily Dose | Duration of a Treatment Course | Price(Yuan) | Annual Treatment Cost (Ten Thousand Yuan) | Average Annual Cost of Treatment(Ten Thousand Yuan) |
|---|---|---|---|---|---|---|
FD | Agalsidase Alfa Concentrated Solution for Infusion | 12 mg | 1 × 27 | 3100(3.5 ml:3.5 mg/vial) | 28.70 | 28.70 |
NPD | Miglustat | 600 mg | 365 | 128(100 mg/capsule) | 28.03 | 28.03 |
Hemophilia | Recombinant Human Coagulation Factor VIIa for Injection | 10.8 mg | 1 × 20.5 | 14467.66(5 mg/vial) | 64.06 | 20.92 |
Recombinant Coagulation Factor IX for Injection | 1500IU | 3 × 13 | 5963.63(1000IU/vial) 3508.2(500IU/vial) | 34.89 | ||
Recombinant Coagulation Factor IX | 1500IU | 3 × 13 | 888(500IU) | 10.39 | ||
Recombinant Coagulation Factor VIII | 1500IU | 3 × 20.5 | 889.95(500IU/vial) 1512.92(1000IU/vial) | 13.96 | ||
Human Coagulation Factor VIII | 4500IU | 1 × 20.5 | 370(200IU/vial) | 17.06 | ||
Desmopressin Injection | 36 µg | 2 × 20.5 | 50.05(15ug/ml/vial) | 0.49 | ||
Human Prothrombin Complex | 1500IU | 3 × 13 | 192(200IU/vial) | 5.62 | ||
MS | Ofatumumab Injection | 20 mg | 1 × 12 | 6778(0.4 ml:20 mg/vial) | 8.13 | 8.00 |
Dimethyl Fumarate Enteric Capsules | 480 mg | 365 | 60.8(240 mg/capsule) | 4.44 | ||
Fingolimod Hydrochloride Capsules | 0.5 mg | 365 | 228(0.5 mg/capsule) | 8.32 | ||
Siponimod Tablets | 2 mg | 365 | 49.26(0.25 mg/tablet) 242(2 mg/tablet) | 8.83 | ||
Teriflunomide Tablets | 14 mg | 365 | 282(14 mg/tablet) | 10.29 | ||
SSc | Nintedanib esilate soft capsules | 300 mg | 365 | 126.68(150 mg/capsule); | 3.65 | 3.65 |
PD | Droxidopa Capsules | 600 mg | 365 | 8.53(100 mg/capsule) | 1.87 | 0.67 |
Ropinirole Hydrochloride Tablets | 3 mg | 365 | 8.145(0.5 mg/tablet) | 1.78 | ||
Rasagiline Mesylate Tablets | 1 mg | 365 | 29.5(1 mg/tablet) | 1.08 | ||
Levodopa Tablets | 3500 mg | 365 | 0.375(0.25 g/tablet) | 0.19 | ||
Pramipexole Dihydrochloride Tablets | 1.5 mg | 365 | 8.38(1.5 mg/tablet) | 0.31 | ||
Entacapone,Levodopa and Carbidopa Tablets | Levodopa,100 mg Carbidopa,25 mg Entacapone,200 mg | 365 | 7.667 (Levodopa 100 mg, Carbidopa 25 mg, Entacapone 200 mg) | 0.280 | ||
Carbidopa and Levodopa Sustained-release Tablets | Carbidopa,125 mg Levodopa,1250 mg | 365 | 1.66 (Carbidopa, 25 mg Levodopa, 250 mg) | 0.30 | ||
Selegiline Hydrochloride Tablets | 10 mg | 365 | 2.895(5 mg/tablet) | 0.21 | ||
Amantadine Hydrochloride Tablets | 200 mg | 365 | 0.11(0.1 g/tablet) | 0.008 |