Prospective associations of psychosocial adversity in childhood with risk factors for cardiovascular disease in adulthood: the MRC National Survey of Health and Development

Table 2 Associations of cumulative psychosocial adversity in childhood and CVD risk factors at mean age 64 years

	Adjusted for age, sex and childhood SEP
	B (95% CI)	P
BMI (kg/m²)	0.02 (-0.25, 0.29)	0.88
Waist circumference (cm)	0.14 (-0.53, 0.82)	0.68
SBP (mm/Hg)	0.22 (-0.79, 1.22)	0.67
DBP (mm/Hg)	0.27 (-0.28, 0.82)	0.34
Insulin (u/ml)	1.02 (0.97, 1.06)	0.43
Glucose (mmol/l)^a	-0.01 (-0.08, 0.06)	0.83
Triglycerides (mmol/l)^a	1.01 (0.98, 1.05)	0.37
HDL-c (mmol/l)	-0.01 (-0.03, 0.02)	0.64
LDL-c (mmol/l)	-0.03 (-0.09, 0.03)	0.38
CRP (mmol/l)^a	1.01 (0.96, 1.07)	0.60
CIMT (mm)	0.001 (-0.01, 0.01)	0.55
Pulse wave velocity (m/s)	-0.15 (-0.51, 0.20)	0.40

SEP – socioeconomic position. BMI-body mass index. SBP – systolic blood pressure. DBP – diastolic blood pressure. HDL-c – high density lipoprotein cholesterol. LDL-c - low density lipoprotein cholesterol. CRP – C reactive protein. CIMT – carotid intima-media thickness.
^aCoefficients for insulin, triglycerides and CRP have been back transformed from the natural log and can be interpreted as a ratio of geometric means, (e.g. a coefficient of 1.02 would be interpreted as an average of 2% increase in the outcome per category increase in cumulative psychosocial adversity)

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