Table 2 Clinical and socioeconomic characteristics of the study population
Variables and categories | Total (n) | % of Total | Survival (median, in years) | Status at five-year follow-up | Hazard ratio (CI95%)at five years* | |||
|---|---|---|---|---|---|---|---|---|
Dead | Censored cases | |||||||
Alive | Attrition | p | ||||||
Children’s life status | 294 | 100% | 4.1 | 43.9% | 44.6% | 11.6% | ||
Characteristics of social stratification of the home | ||||||||
Maximum educational level (parents) | ||||||||
University degree or higher | 63 | 21.4% | 3.7 | 46.0% | 42.9% | 11.1% | 0.355 | (Reference group) |
Bachelor’s/technical degree | 109 | 37.1% | 4.4 | 45.0% | 47.7% | 7.3% | 0.96 (0.60, 1.51) | |
High school | 101 | 34.4% | 3.8 | 38.6% | 44.6% | 16.8% | 0.86 (0.53, 1.39) | |
Primary school or less | 21 | 7.1% | 4.4 | 57.1% | 33.3% | 9.5% | 1.21 (0.62, 2.38) | |
Monthly family income level, median [range] USD a | ||||||||
Q4: 644 [481, 2910] | 72 | 24.5% | 4.9 | 31.9% | 50.0% | 18.1% | 0.125 | (Reference group) |
Q3: 355 [294, 477] | 67 | 22.8% | 3.3 | 53.7% | 40.3% | 6.0% | 1.82 (1.08, 3.08)* | |
Q2: 218 [165, 291] | 80 | 27.2% | 3.9 | 48.8% | 41.3% | 10.0% | 1.61 (0.96, 2.70) | |
Q1: 126 [73, 162] | 75 | 25.5% | 3.8 | 41.3% | 46.7% | 12.0% | 1.44 (0.84, 2.47) | |
Availability of basic services in the homeb | ||||||||
All three services | 269 | 91.5% | 4.3 | 42.0% | 46.8% | 11.2% | 0.035 | (Reference group) |
Without at least one | 25 | 8.5% | 2.1 | 64.0% | 20.0% | 16.0% | 1.88 (1.12, 3.18)* | |
Maximum occupational level (parents) | ||||||||
Managers and professionals | 29 | 9.9% | 4.9 | 37.9% | 51.7% | 10.3% | 0.473 | (Reference group) |
Mid-level and support workers | 128 | 43.5% | 3.6 | 49.2% | 41.4% | 9.4% | 1.43 (0.76, 2.72) | |
Service, sales, and skilled workers | 68 | 23.1% | 3.4 | 45.9% | 39.7% | 14.7% | 1.40 (0.71, 2.79) | |
Machine operators; unskilled laborers and unemployed | 69 | 23.5% | 4.9 | 34.8% | 52.2% | 13.0% | 0.92 (0.45, 1.88) | |
Proportion of minor’s life insured by IMSS prior to ALL diagnosis | ||||||||
80–100% | 149 | 50.7% | 5.0 | 36.2% | 55.7% | 8.1% | 0.003 | (Reference group) |
50–80% | 64 | 21.8% | 3.5 | 42.2% | 40.6% | 17.2% | 1.27 (0.80, 2.02) | |
25–50% | 34 | 11.6% | 2.5 | 61.8% | 26.5% | 11.8% | 2.02 (1.22, 3.36)* | |
0–25% | 47 | 16.0% | 2.3 | 57.4% | 27.7% | 14.9% | 2.09 (1.32, 3.32)* | |
Clinical characteristics of minor | ||||||||
Age group at ALL diagnosis (years) | ||||||||
< 1 | 9 | 3.1% | 1.1 | 77.8% | 22.2% | 0.0% | 0.000 | 4.00 (1.80, 8.91)* |
1 to < 5 | 126 | 42.9% | 5.0 | 34.9% | 57.1% | 7.9% | (Reference group) | |
5 to < 10 | 81 | 27.6% | 4.7 | 44.4% | 46.9% | 8.6% | 1.33 (0.86, 2.07) | |
10 to < 15 | 78 | 26.5% | 2.5 | 53.8% | 24.4% | 21.8% | 1.92 (1.26, 2.94)* | |
Sex | ||||||||
Female | 132 | 44.9% | 3.9 | 42.4% | 47.0% | 10.6% | 0.734 | (Reference group) |
Male | 162 | 55.1% | 4.0 | 45.1% | 42.6% | 12.3% | 1.04 (0.74, 1.48) | |
ALL risk diagnosis | ||||||||
Standard risk | 143 | 48.6% | 4.9 | 35.0% | 56.6% | 8.4% | 0.000 | (Reference group) |
High risk | 151 | 51.4% | 2.5 | 52.3% | 33.1% | 14.6% | 1.87 (1.31, 2.67)* | |
Time lag in diagnosis | ||||||||
< 1 month | 125 | 42.5% | 3.8 | 44.8% | 44.0% | 11.2% | 0.465 | (Reference group) |
1 to 4 months | 139 | 47.3% | 3.8 | 45.3% | 41.7% | 12.9% | 1.07 (0.74, 1.54) | |
> 4 months | 30 | 10.2% | 5.0 | 33.3% | 60.0% | 6.7% | 0.67 (0.35, 1.33) | |
Diagnosis cohort | ||||||||
2007 | 103 | 35.0% | 2.8 | 46.6% | 34.0% | 19.4% | 0.006 | (Reference group) |
2008 | 94 | 32.0% | 4.9 | 38.3% | 55.3% | 6.4% | 0.67 (0.44, 1.04) | |
2009 | 97 | 33.0% | 4.3 | 46.4% | 45.4% | 8.2% | 0.85 (0.57, 1.28) | |
Proportion of treatment period of IMSS-insured minor (after ALL diagnosis) | ||||||||
75–100% | 258 | 87.8% | 3.8 | 47.3% | 44.6% | 8.1% | 0.000 | (Reference group) |
50% to < 75% | 17 | 5.8% | 4.6 | 23.5% | 47.1% | 29.4% | 1.505 (0.14, 16.6) | |
25 to < 50% | 11 | 3.7% | 2.9 | 18.2% | 36.4% | 45.5% | 1.687 (0.19, 15.1) | |
< 25% | 8 | 2.7% | 4.8 | 12.5% | 50.0% | 37.5% | 4.112 (0.57, 29.4) | |
Characteristics of the community and the medical service network | ||||||||
Area of residence | ||||||||
Metropolitan | 252 | 85.7% | 4.3 | 43.3% | 46.0% | 10.7% | 0.347 | (Reference group) |
Provincial | 42 | 14.3% | 2.7 | 47.6% | 35.7% | 16.7% | 1.31 (0.81, 2.11) | |
Level of marginalization of the municipality of residence | ||||||||
Very low or low | 243 | 82.7% | 4.3 | 43.2% | 45.7% | 11.1% | 0.589 | (Reference group) |
Medium | 42 | 14.3% | 3.3 | 45.2% | 38.1% | 16.7% | 1.22 (0.75, 1.99) | |
High or very high | 9 | 3.1% | 3.6 | 55.6% | 44.4% | 0.0% | 1.42 (0.58, 3.49) | |
Network of services | ||||||||
La Raza | 205 | 69.7% | 4.6 | 41.0% | 48.3% | 10.7% | 0.148 | (Reference group) |
SXXI | 89 | 30.3% | 2.6 | 50.6% | 36.0% | 13.5% | 1.45 (1.01, 2.09)* | |
Distance from tertiary hospital (km) | ||||||||
< 20 | 119 | 40.5% | 3.9 | 47.1% | 43.7% | 9.2% | 0.037 | (Reference group) |
20 to < 50 | 96 | 32.7% | 4.4 | 40.6% | 46.9% | 12.5% | 0.85 (0.56, 1.28) | |
50 to < 200 | 58 | 19.7% | 4.9 | 43.1% | 50.0% | 6.9% | 0.91 (0.57, 1.46) | |
≥ 200 | 21 | 7.1% | 1.1 | 42.9% | 23.8% | 33.3% | 1.32 (0.65, 2.67) | |
Type of secondary-level hospitalc | ||||||||
General; regional | 83 | 28.2% | 4.6 | 45.8% | 44.6% | 9.6% | 0.658 | (Reference group) |
General; zone | 205 | 69.7% | 4.1 | 42.4% | 45.4% | 12.2% | 0.90 (0.62, 1.32) | |
General; subzone | 6 | 2.0% | 0.9 | 66.7% | 16.7% | 16.7% | 2.24 (0.80, 6.29) | |
Distance from secondary hospital (km) | ||||||||
< 5 | 176 | 59.9% | 3.9 | 44.3% | 44.9% | 10.8% | 0.568 | (Reference group) |
5 to < 10 | 56 | 19.0% | 3.2 | 42.9% | 50.0% | 7.1% | 1.19 (0.77, 1.83) | |
10 to < 20 | 44 | 15.0% | 4.3 | 45.5% | 36.4% | 18.2% | 0.78 (0.46, 1.34) | |
≥ 20 | 18 | 6.1% | 4.4 | 50.0% | 33.3% | 16.7% | 0.85 (0.37, 1.94) | |